The A1084 Brigg Road between Grasby and Clixby will be closed for resurfacing from September 9 to 12.
Three sections of the road, totalling 1173 metres, will be resurfaced with nearly 700 tonnes of tarmac.
A diversion will be in place directing traffic via the A1084 Brigg Road, Bigby Hill, Bugby High Road, B1434 Howsam Road, Brigg Road, B1205 Station Road, Moortown Road, A46 Caistor Road, Nettleton Road, Caistor Bypass, Grimsby Road, A1173, A1084, High Street, Brigg Road and vice versa.
Highways manager for Lincolnshire County Council, Steve Wiles, said: “We are taking this opportunity to resurface a large section of the road, rather than simply filling individual potholes.
“This will ensure the road remains in good condition for many more years and is a more cost-effective option.
“During the work we will have to close the road, but we will ensure access is maintained for residents who live along this stretch.”